ntervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (treat earlier): a randomised, double-blind, placebo-controlled, proof-of-concept trial

Answers

Answer 1

The study you mentioned is a randomized, double-blind, placebo-controlled, proof-of-concept trial. It aims to investigate the effectiveness of methotrexate intervention in patients with arthralgia who are at risk of developing rheumatoid arthritis. The goal is to reduce the development of persistent arthritis and its associated burden.


The trial is randomized, which means that participants are assigned to different groups randomly. This helps to eliminate bias and ensure that the results are reliable. It is double-blind, meaning that both the participants and the researchers involved in the study are unaware of which group is receiving the actual treatment (methotrexate) and which group is receiving a placebo. This helps to minimize any potential bias and ensures that the results are objective.

The trial is placebo-controlled, which means that one group receives a placebo (a dummy treatment with no active ingredients) while the other group receives the actual treatment (methotrexate). This is done to compare the effects of the treatment against the effects of the placebo and determine its  trial aims to prove the concept of using methotrexate intervention in patients with arthralgia at risk of rheumatoid arthritis. By conducting this trial, the researchers want to gather evidence on whether methotrexate can reduce the development of persistent arthritis and alleviate the burden of the disease.

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Related Questions

What percentage of all hospitalized patients in the united states have at least one hai?.

Answers

3% of hospitalized patients in the 2015 survey had one or more HAI.There were an estimated 687.000 HAIs in U.S acute care hospitals in 2015.About 72,000 hospital patients with HAIs died during their hospitalizations.

Laboratory testing is ordered for Maria. Based on Maria's signs and symptoms, you expect the laboratory results to reveal (select all that apply):

Answers

Answer:

Sepsis disease.

Explanation:

Maria has a symptoms of body swelling, reduced urine output and difficulty in breathing. The disease can be caused by fungal infection or bacteria attack. Body swelling is the major symptom of this disease. The laboratory report is expected to result in Sepsis positive.

Blood pressure (What is healthy and unhealthy blood pressure for a teenager?):

Answers

Answer:

A teenager may have an acceptable blood pressure of 110/70 mm Hg, but that value would be of concern in a toddler. The National Heart, Lung, and Blood Institute has prepared a series of age- and gender-specific blood pressure measurement tables for children ages 3 through 17 years, based on percentiles.

Answer:

ok a good blood pressure is less than 120/80  a  not  so good blood pressure is higher like : 140/90  is higher

Explanation:

is ascorbyl‑palmitate hydrophilic, hydrophobic, or amphipathic?

Answers

Ascorbyl-palmitate is an amphipathic molecule, meaning that it is capable of forming both hydrophobic (water-fearing) and hydrophilic (water-loving) interactions.

A hydrophilic ascorbic acid (vitamin C) molecule is joined to a hydrophobic palmitic acid molecule to form ascorbyl-palmitate.

While the hydrophobic portion of the molecule prefers to associate with non-polar molecules like oils and fats, the hydrophilic portion can establish hydrogen bonds with water molecules.

Given that it may aid in the dissolution of both water-soluble and oil-soluble substances, the molecule's dual nature makes it a perfect element for usage in cosmetic and skincare products.

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In the insurance industry, _______ means protection against income losses for illnesses or injury, disability income, and accidental death or dismemberment.

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In the insurance industry, health insurance means protection against income losses for illnesses or injury, disability income, and accidental death or dismemberment.

A type of insurance coverage called health insurance covers medical and health-related costs. The expenditures of routine care, emergency care, and treatment for chronic conditions are all partially or entirely covered by health insurance.Customers of health insurance firms pay a monthly fee for coverage, and in return, the company commits to cover all or the majority of the customer's medical expenses. Even under the most generous plans, insured individuals are still required to cover a variety of out-of-pocket costs for medical care.These expenditures mostly consist of copays and deductibles, which are upfront payments made by the insured to healthcare providers prior to receiving services.Private insurance and public insurance are the two main forms of health insurance policies.

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Which of the following can be compounded in a segregated compounding area (SCA)?

Answers

Segregated compounding area means a designated space, either a demarcated area or room, which is restricted to preparing low-risk preparations with 12-hour or less beyond-use date.

CSPs have longer BUDs and are made in a cleanroom suite. When determining BUDs for Category 2 CSPs, the updated "797" outlines a number of variables to take into account, including the aseptic processing and sterilizing procedure, beginning components, sterility testing, and storage conditions.

If additional criteria are satisfied, Category 3 CSPs may be awarded BUDs that are up to 180 days longer than those for Category 1 or Category 2 CSPs. For all CSPs needing sterility testing, a cap of 250 ultimate yield units per batch has been added.

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Match the given work profiles to their respective job roles. NEED ASAP​

Match the given work profiles to their respective job roles. NEED ASAP

Answers

Answer:

Matt- Public Health Officer

Rose- Veterinary Researcher

Georgia- Food Safetey Officer

Kane- Veterinary Professor

Shea is a registered nurse. Which of the given roles would come under her scope of work?

A. Clean the patient’s house regularly

B. Provide emotional and physical support to the patient

C. Purchase groceries for the patient

D. Ensure esthetic requirements are met on client’s request

Answers

Answer:

B

Explanation:

I took the test on Plato/edmentum and got it right

Common behaviors that are a result of Alzheimer's disease are

Answers

Answer:

angry outbursts and physical aggression, hand wringing pacing and rocking, accusing loved ones of wrong doing and hallucinating, repeating stories and leaving the house unassisted, sleep problems and sundowing

Explanation:

1, Verbal or physical aggression, which can be quite alarming, is common in patients with Alzheimer’s.

2, Dementia makes it very difficult to process stimuli and new information, causing many people with Alzheimer’s disease to become anxious. 

3, Caregivers may feel at a loss when an Alzheimer’s patient exhibits behavior that is clearly not grounded in reality: either hallucinations—perceiving something that isn’t really there—or delusions, which are false beliefs that can lead to paranoia.

4, The memory problems caused by Alzheimer’s disease can lead to a range of distressing behaviors, including repetition of words or activities, disorientation even in familiar places, and, in severe cases, confusion about the passage of time.

5, It’s not well understood why sleep disturbances occur in many Alzheimer’s patients, but it’s common for them to experience nighttime restlessness and changes to their sleep schedule.

The client is diagnosed with chronic skin hardening, which is noticeable in the stiffness of facial expressions. What is this condition called?

Answers

The condition is Scleroderma.

Mary approaches you and says that you could save time by not washing your hands so much she tells you that if you are wearing gloves you don’t have to wash your hands after you take them off how do you respond to Marie and what action should you take

Answers

Answer:

i would respond as

Explanation:

Washing your hands is the best way to stop germs from spreading. ... You can't wear rubber gloves all day long, but you can wash your hands so ... But did you know that a lot of people don't know how to get their paws perfectly clean? The next time you're told to step up to the sink and scrub up, remember these handy hints:. WASH YOURB HANDS

Medical term for shingles?

Answers

Answer:

Shingles is medically known as "herpes zoster", which comes from the varicella zoster virus.

Explanation:

Answer:

Herpes Zoster

some help me pleasez​

some help me pleasez

Answers

Answer:

I think it would be A/1

Explanation:

C would be the correct answer because of the ketchup having sugars.

What are the priority nursing actions you would anticipate implementing when caring for Mr. Jones and why

Answers

Answer:

At first i could see the patient's diagnosis so that i could know what is the disease condition of patient and why is he been admittedi will take a past and present history ( how many year has been patient is affected from disease condition, does he/she smoke ,drink :if yes then i could lije to do counseling )suggest them to take medicine in proper time i could see the list of medication prescribed bt doctor if any medication is not present then i could suggest them to bring itTime to time analysing the patientif there is any problem and i could not know then i should immediately inform the staff sister or my senior

what happens in the body when you're sleeping which systems are working

Answers

Answer:

Your pulse, body temperature, breathing, and blood pressure rise to daytime levels. Your sympathetic nervous system, which helps with automatic responses like “fight or flight,” gets very active.

What are the main differences between OTC drugs and dietary supplements?.

Answers

One major difference between OTC drugs and dietary supplements is how they’re regulated and tested. In general, the FDA considers new drugs to be unsafe until they are proven safe. Dietary supplements, however, are not regulated by the FDA.

what are OTC drugs ?

Over-the-counter or OTC medicines, vitamins and dietary supplements do not require a prescription. You can purchase them at grocery and convenience stores, pharmacies.

Dietary supplements are intended to add to or supplement the diet and are different from conventional food.

Dietary supplements are substances you might use to add nutrients to your diet or to lower your risk of health problems such as osteoporosis or arthritis.

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Which Gestalt law of organization is BEST demonstrated in this image?

A.
law of harmony

B.
law of closure

C.
law of proximity

D.
law of similarity

Which Gestalt law of organization is BEST demonstrated in this image? A. law of harmony B. law of closure

Answers

D the law of similarity hope this helps <3

The law of similarity, the Gestalt law of organization is best demonstrated in this image. Therefore, the correct option is D.

According to the Gestalt psychology principle, the law of similarity, people tend to think of objects as similar to each other. According to this theory, objects with similar characteristics are grouped together by our visual system. When two or more of these characteristics are shared by objects, it is assumed that they belong to the same class or group.

For example, the law of similarity predicts that if you have a collection of circles and squares of different sizes, you will probably see circles as one group and squares as another group.

Therefore, the correct option is D.

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data on marijuana use can be used to make a broader statement that illicit drug use among high school seniors has not changed a great deal in the past 20 years because

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Data on  marijuana use is just one type of information among many that can be used to analyze trends in illicit drug use among high school seniors.

However, in order to draw broader conclusions regarding the state of drug usage through time, it is crucial to take into account additional data sources, such as details on other classes of illicit drugs and patterns among different age groups. It can also be challenging to draw general conclusions regarding the usage of illicit drugs without taking these aspects into account because of how data collection methods have changed, how society views drug use, and other reasons.

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What is the major difference between dissociative amnesia and retrograde amnesia.

Answers

The major difference between dissociative amnesia and retrograde amnesia is the cause and type of information that is forgotten.

What is amnesia?

This is a disease or condition in which it is difficult for patients to remember specific information.

What is dissociative amnesia?

This type of amnesia implies patients cannot remember relevant information such as one's name, one's location, specific events or feelings.

This is often caused due to traumatic events or stress.

What is retrograde amnesia?

This type of amnesia implies patients cannot remember information from their past. This means patients can remember the events that are happening today, but not the ones yesterday, last year, etc.

This is often caused by brain injury or diseases such as Alzheimer's disease or a cardiac arrest.

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Where in the gastrointestinal track do drugs delivered orally have their highest absorption?

Answers

Answer: The small intestine

Explanation:

In a neuron with a resting membrane potential of -85 mV, which ion LEAST contributes to the generation of the value of resting potential?
Choose one answer:
a. Potassium
b. Calcium
c. Chloride
d. Sodium
e. This cannot be stated

Answers

Answer:

e. This cannot be stated.

Explanation:

Potassium , Calcium , Chloride  and Sodium are the ions that contributes to the generation of the value of resting potential. There is no example of such an ion which causes the least contributes to the generation of the value of resting potential so that's why we choose option E. The resting membrane potential (RMP) occurs due to changes in the permeability of membrane for potassium, sodium, calcium, and chloride, which leads to the movement of these ions across it.

Food service workers should always wash their hands after using the restroom to help prevent __________ transmission of foodborne illness.

Answers

The washing of hands of food workers after using the toilet helps prevent feacal oral transmission of foodborne diseases.

Meaning of fecal oral transmission of diseases.

Fecal oral is a process of disease transmission through the feaces of an infected food worker to a non infected individual or customer.

This transmission occurs when food workers fail to sanitize properly after using the rest room

In conclusion poor sanitation is dangerous and we all must learn to wash our hands after using the toilet.

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Upon examination of the head and neck of a client, a nurse notes that the submandibular nodes are tender and enlarged. the nurse should assess the client for further findings related to what condition?

Answers

Patients requiring pre- and post-operative care, or those with other urgent medical concerns, are included in acute care. They may also have endured severe illness or trauma. Rapid intervention in time-sensitive situations is the primary focus of acute care registered nurses.

An infection is the invasion and proliferation of a bacterium within the body, according to Open Resources for Nursing (Open RN). Infection can develop into a disease that manifests as signs and symptoms and alters the host's natural structure or functionality.

evaluating, watching, and conversing with patients keeping a record of the symptoms, medical history, and state of health of the patient. patient preparation for examinations and treatment. administering drugs and treatments, then keeping track of patients' reactions and negative effects.

Acute care is a general word that refers to a variety of clinical health-care activities, such as emergency medicine, trauma care, pre-hospital emergency treatment, acute care surgery, critical care, urgent care, and short-term inpatient stabilization.

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Relating to special evaluation and Management services basic life and on or disability evaluation services and work-related or medical disability evaluation services are only used when the insurance is asking for specific examination claims true or false

Answers

False. Basic life and disability evaluation services, as well as work-related or medical disability evaluation services, can be used for various reasons beyond insurance claims, such as employer requests or individual needs for government benefits or accommodations.

Basic life and disability evaluation services, as well as work-related or medical disability evaluation services, can be used for various reasons beyond insurance claims. For example, employers may request disability evaluations to determine if an employee is able to perform their job duties, or individuals may seek disability evaluations to qualify for government benefits or accommodations. Insurance companies may request these services as part of their claims process, but they are not the only ones who can request them.

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How can you display tactful behavior when communicating with providers about 3rd party (insurance) requirements- you can formulate your response around how we can discuss pre-authorization requirements before being able to perform a service on a patient
How can you show sensitivity when communicating with patients about 3rd party (insurance) requirements- you can formulate your response around how you can discuss the requirement for collecting patient copay/coinsurance/deductible at the time of service

Answers

Answer:

To show sensitivity when communicating with patients about 3rd party (insurance) requirements, it is important to approach the conversation with empathy and understanding. Here are some possible ways to discuss the requirement for collecting patient copay/coinsurance/deductible at the time of service:

Explain the reason for the requirement: Start by explaining to the patient that insurance companies require copays/coinsurance/deductibles to ensure that the cost of healthcare is shared between the patient and the insurance provider. This helps to keep premiums more affordable and sustainable for everyone.

Use clear language: Avoid using technical jargon that may confuse or intimidate the patient. Use simple, clear language to explain what the requirement is, how it works, and what it means for the patient.

Provide options: Be prepared to offer the patient different payment options or payment plans that can help them meet their financial obligations. This could include setting up a payment plan or discussing financial assistance programs that may be available.

Be patient: Patients may be frustrated or stressed about their financial obligations, so it is important to remain patient and understanding. Allow the patient to ask questions and address their concerns before moving on to the next topic.

Show empathy: Acknowledge the patient's concerns and express empathy for their situation. Let them know that you understand their concerns and that you are there to help them navigate the process. This can help to build trust and establish a positive rapport with the patient.

the nurse is planning to use a pre-packaged kit to prepare a sterile field. which would be of least importance in ensuring sterility of the kit?

Answers

The least important factor in ensuring the sterility of a pre-packaged kit for a sterile field.

When using a pre-packaged kit to prepare a sterile field, all measures must be taken to maintain sterility. Among the options provided, the least important factor in ensuring the sterility of the kit would be option A) "storing the kit in a clean, dry place."

While proper storage is generally important to maintain the integrity of medical supplies, it is not directly related to the immediate sterility of the kit during its use.Instead, other factors play a more critical role in ensuring sterility. These include properly sealing and maintaining the packaging of the kit until its intended use, checking for any signs of damage or tampering, and verifying the expiration date to ensure the contents are still sterile. Additionally, following aseptic techniques during the preparation and handling of the kit, such as hand hygiene, wearing sterile gloves, and using sterile instruments, are crucial to maintaining the sterility of the field.

While storing the kit appropriately is important for long-term storage, it does not directly impact the sterility of the kit during its intended use, making it the least important factor in this context.

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Coumarin toxicity, found when animals ingest rat poisoning, is treated with.
a.heparin.
b.vitamin K1.
c.EDTA.
d.silver nitrate sticks.

Answers

Coumarin toxicity, found when animals ingest rat poisoning, is treated with b. vitamin K1.

Coumarin is a type of anticoagulant, which means that it prevents the blood from clotting. When animals ingest rat poisoning, they can develop coumarin toxicity, which can lead to excessive bleeding and hemorrhaging.

The most effective treatment for coumarin toxicity is vitamin K1, which helps to promote the clotting of blood and prevent excessive bleeding. Heparin, EDTA, and silver nitrate sticks are not effective treatments for coumarin toxicity. In summary, the correct answer is b. vitamin K1.

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According to the research of Wilhelm Wundt and other structuralists, which of the
following is an example of a subjective state?
A- scent of floral bouquet
B- mental image of a floral bouquet
C- feel of a flower petal on skin
D- sound of a bee in flowers

Answers

B- mental image of a floral bouquet
B is an example of a subjective state.

What does a major medical insurance plan do?

Answers

A specific type of health insurance plan that will help you cover your medical expenses. It covers stuff like urgent care visits, emergency room visit, prescription medication‘s, and other medical expenses.

A remainder of a claim not paid by the insurance carrier that is later billed to the patient is called.

Answers

The answer A balance bill is issued when a provider charges a patient with the amount the insurance company doesn't pay. For example, the dermatologist charges the insurance company $300. The insurance company agreed to pay $150. If the doctor then charges the patient the remaining $150, the patient will receive a balance bill.
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